This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Yilmaz, M Articles by Buyukhatipoglu, H Search for Related Content PubMed PubMed Citation Articles by Yilmaz, M Articles by Buyukhatipoglu, H Pubmed/NCBI databases Medline Plus Health Information Lupus Social Bookmarking                         What's this?

Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto’s disease) mimicking systemic lupus erythematosus: a review of two cases

Department of Hematology, Gaziantep University, School of Medicine, Gaziantep, Turkey

C Camci

Medical Oncology, Gaziantep University, School of Medicine, Gaziantep, Turkey

I Sari

Pathology, Gaziantep University, School of Medicine, Gaziantep, Turkey

V Okan

Department of Hematology, Gaziantep University, School of Medicine, Gaziantep, Turkey

A Sevinc

Medical Oncology, Gaziantep University, School of Medicine, Gaziantep, Turkey

A M Onat

Rheumatology, Gaziantep University, School of Medicine, Gaziantep, Turkey

H Buyukhatipoglu

Internal Medicine, Gaziantep University, School of Medicine, Gaziantep, Turkey, buyukhatipoglu{at}gmail.com

Kikuchi-Fujimoto’s disease (KFD), or histiocytic necrotizing lymphadenitis, is a benign and self-limited lymphadenitis commonly found in young women. It often shares clinical features with systemic lupus erythematosus (SLE), such as arthralgias, fever and leukopenia. The etiology of KFD remains unknown and controversial. Clinical course is favorable, with spontaneous remission in less than four months in almost all cases. Herein, we present two cases. The former is a 53-year old woman presenting with cervical lymphadenopathy, arthralgia, pancytopenia and positive antinuclear antibody (ANA). Lymph node biopsy revealed histopathological features compatible with Kikuchi-Fujimoto histiocytic necrotizing lymphadenitis. The latter patient was a 20-year old woman presenting with left cervical lympadenopathy, a butterfly rash that was reminiscent of SLE, and a positive antinuclear antibody. Based upon clinical, histological and laboratory findings, the diagnosis of SLE was excluded. Careful attention should be paid to differentiating between KFD and SLE, because of their similar presentations, yet different clinical courses and therapeutic requirements.

Key Words: Kikuchi-Fujimoto’s disease • lymphadenopathy • pancytopenia • systemic lupus erythematosus

Lupus, Vol. 15, No. 6, 384-387 (2006)
DOI: 10.1191/0961203306lu2320cr


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?