Lupus

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kallenberg, C.
Right arrow Articles by Limburg, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kallenberg, C.
Right arrow Articles by Limburg, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Lupus, Vol. 15, No. 7, 397-402 (2006)
DOI: 10.1191/0961203306lu2323oa

Quantitation of Autoantibodies in Systemic Autoimmune Diseases: Clinically Useful?

CGM Kallenberg

Department of Internal Medicine, University Medical Center Groningen and University of Groningen, The Netherlands, c.g.m.kallenberg{at}int.umcg.nl

CA Stegeman

Department of Internal Medicine, University Medical Center Groningen and University of Groningen, The Netherlands

H Bootsma

Department of Internal Medicine, University Medical Center Groningen and University of Groningen, The Netherlands

M Bijl

Department of Internal Medicine, University Medical Center Groningen and University of Groningen, The Netherlands

PC Limburg

Department of Internal Medicine, University Medical Center Groningen and University of Groningen, The Netherlands

Serial assessment of levels of autoantibodies has been proposed as being clinically useful in certain systemic autoimmune diseases. In particular, attention has been given to anti-dsDNA antibodies in systemic lupus erythematosus (SLE) and ANCA in the ANCA-associated vasculitides (AAV). Much controversy exists, however, concerning the value of serial testing in these diseases. We here review the various tests available for quantitation of anti-dsDNA and ANCA, and their capacity to detect changes in autoantibody levels that are associated with changes in clinical disease activity of the respective diseases. It is concluded that changes in anti-dsDNA as measured by the Farr assay and changes in ANCA as assessed by ELISA have predictive value for the occurrence of disease relapses, although this relationship is far from absolute. Consequently, treatment based on changes in levels of the respective autoantibodies only seems at present not justified, in view of the toxicity of currently available immunosuppressive regimens.

Key Words: anti-dsDNA • anti-neutrophil cytoplasmic antibodies • PR3-ANCA • relapse • SLE • Wegener’s Granulomatosis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Ann. N. Y. Acad. Sci.Home page
A. GHIRARDELLO, D. VILLALTA, G. MOROZZI, A. AFELTRA, M. GALEAZZI, R. GERLI, A. MATHIEU, P. L. MERONI, P. MIGLIORINI, A. RADICE, et al.
Evaluation of Current Methods for the Measurement of Serum Anti Double-Stranded DNA Antibodies
Ann. N.Y. Acad. Sci., August 1, 2007; 1109(1): 401 - 406.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
Y Shoenfeld
Novel Aspects of Diagnostic Test: Multiple Autoantigens, New Algorithms and Revolutionary Techniques
Lupus, July 1, 2006; 15(7): 389 - 390.
[PDF]