This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Gómez-Puerta, J. Articles by Cervera, R Search for Related Content PubMed PubMed Citation Articles by Gómez-Puerta, J. Articles by Cervera, R Pubmed/NCBI databases Medline Plus Health Information Lupus Social Bookmarking                         What's this?

Anti-Chromatin (Anti-Nucleosome) Antibodies

Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Catalonia, Spain

RW Burlingame

INOVA Diagnostics, Inc., San Diego, CA, USA

R Cervera

Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Catalonia, Spain, rcervera{at}clinic.ub.es

Chromatin is the native complex of histones and DNA found in the cell nucleus of eukaryotes. The fundamental subunit of chromatin is the nucleosome, which is composed of a core particle in which 146 bp of helical DNA are wrapped around an octamer made up of two H2A-H2B dimers that surround an H3-H4 tetramer. The prevalence of anti-chromatin (nucleosome) antibodies in systemic lupus erythematosus (SLE) varies from 50% to 90%, being similar to that of the classical positive LE cell. The presence of these antibodies can be used, in conjunction with clinical findings and other laboratory tests, to help in the diagnosis of SLE and drug induced lupus. The presence of anti-chromatin antibodies has also been linked to glomerulonephritis in SLE patients.

Key Words: anti-chromatin antibodies • anti-nucleosome antibodies • drug induced lupus • systemic lupus erythematosus

Lupus, Vol. 15, No. 7, 408-411 (2006)
DOI: 10.1191/0961203306lu2325oa


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				G Schett, H Dumortier, E Hoefler, S Muller, and G Steiner B cell epitopes of the heterogeneous nuclear ribonucleoprotein A2: identification of a new specific antibody marker for active lupus disease Ann Rheum Dis, May 1, 2009; 68(5): 729 - 735. [Abstract] [Full Text] [PDF]

				A Souza, L. da Silva, F. Oliveira, A. Roselino, and P Louzada-Junior Anti-nucleosome and anti-chromatin antibodies are present in active systemic lupus erythematosus but not in the cutaneous form of the disease Lupus, March 1, 2009; 18(3): 223 - 229. [Abstract] [PDF]

				S Muller, J Dieker, A Tincani, and P. Meroni Pathogenic anti-nucleosome antibodies Lupus, May 1, 2008; 17(5): 431 - 436. [Abstract] [PDF]

				B. Deocharan, Z. Zhou, K. Antar, L. Siconolfi-Baez, R. H. Angeletti, J. Hardin, and C. Putterman {alpha}-Actinin Immunization Elicits Anti-Chromatin Autoimmunity in Nonautoimmune Mice J. Immunol., July 15, 2007; 179(2): 1313 - 1321. [Abstract] [Full Text] [PDF]

				Y Shoenfeld Novel Aspects of Diagnostic Test: Multiple Autoantigens, New Algorithms and Revolutionary Techniques Lupus, July 1, 2006; 15(7): 389 - 390. [PDF]