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Lupus
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Antigen-Chip Technology for Accessing Global Information about the State of the Body

FJ Quintana

Department of Immunology

Y Merbl

Department of Immunology

E Sahar

ImmunArray, Ltd, Tel Aviv, Israel

E Domany

Department of the Physics of Complex Systems, The Weizmann Institute of Science, Rehovot, Israel

IR Cohen

Department of Immunology, Irun.cohen{at}weizmann.ac.il

Traditionally, immunologic diagnosis has been based on an attempt to correlate each disease with a specific immune reactivity, such as an antibody or a T-cell response to a single antigen specific for the disease entity. The state of the body, however, appears to be encoded by the immune system in collectives of reactivities and not by single reactivities. Here we describe our use of microarray technology and informatics to develop an antigen chip capable of detecting global patterns of antibodies binding to hundreds of antigens simultaneously. The patterns fashion diagnostic signatures.

Key Words: autoantibodies • autoimmunity bioinformatics • immunological homunculus • microarray

Lupus, Vol. 15, No. 7, 428-430 (2006)
DOI: 10.1191/0961203306lu2328oa
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