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Translocation of the novel cytokine HMGB1 to the cytoplasm and extracellular space coincides with the peak of clinical activity in experimentally UV-induced lesions of cutaneous lupus erythematosus

Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, vilija.barkauskaite{at}ki.se

M. Ek

Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

K. Popovic

Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden

H.E. Harris

Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

M. Wahren-Herlenius

Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

F. Nyberg

Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden

HMGB1 is a pro-inflammatory cytokine that together with TNF- and IL-1ß is involved in the pathogenesis of spontaneously occurring skin lesions in lupus erythematosus. The purpose of the present study was to explore the sequence of events in HMGB1, TNF- and IL-1ß expression under development and resolution of experimentally induced CLE lesions. The study involved investigation of 38 serial skin biopsies acquired from photoprovoked skin lesions of nine CLE patients, using immunohistochemical staining of tissue sections. In biopsies from the clinically most active phase of skin involvement extracellular, secreted HMGB1 and increased cytoplasmic HMGB1 were found, as compared with the late and fading lesions or non-lesional skin. Besides HMGB1, increased expression of TNF- and IL-1ß was observed in dermal infiltrates of the induced CLE lesions. These cytokines were however not upregulated in all lesions, and increased expression of IL-1ß was seen predominantly in late biopsies.

In conclusion, extracellular and cytoplasmic HMGB1 coincides with the clinically most active phase of photoinduced lesions of cutaneous lupus, and suggests that HMGB1 is an important factor in the inflammatory autoimmune process of CLE. HMGB1 can induce expression of TNF- and IL-1ß, and formation of a pro-inflammatory loop between HMGB1, TNF-, and IL-1ß may be responsible for the prolonged and sustained inflammation in CLE. Lupus (2007) 16, 794—802.

Key Words: lupus • skin • HMGB1 • TNF- • IL-1ß • photoprovocation

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