This Article Free Full Text (Free PDF) Free References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (9) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Dai, Y. Articles by Yin, Y.-B. Search for Related Content PubMed PubMed Citation Articles by Dai, Y. Articles by Yin, Y.-B. Social Bookmarking                         What's this?

Microarray analysis of microRNA expression in peripheral blood cells of systemic lupus erythematosus patients

The Second Clinical Medical College, Jinan University, Shenzhen People's Hospital, Guangdong Province, China

Y.-S. Huang

Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Chongqing Medical University, Chongqing, China, hys{at}live.cn

M. Tang

Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Chongqing Medical University, Chongqing, China

T.-Y. Lv

The Second Clinical Medical College, Jinan University, Shenzhen People's Hospital, Guangdong Province, China

C.-X. Hu

The Second Clinical Medical College, Jinan University, Shenzhen People's Hospital, Guangdong Province, China

Y.-H. Tan

The Second Clinical Medical College, Jinan University, Shenzhen People's Hospital, Guangdong Province, China

Z.-M. Xu

The Second Clinical Medical College, Jinan University, Shenzhen People's Hospital, Guangdong Province, China

Y.-B. Yin

Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Chongqing Medical University, Chongqing, China

MicroRNAs (miRNAs) are noncoding RNA molecules of 21—24 nt that regulate the expression of target genes in a post-transcriptional manner. Evidence indicates that miRNAs play essential roles in embryogenesis, cell differentiation and pathogenesis of human diseases. This study describes a comparison between the miRNA profile of the systemic lupus erythematosus (SLE) patients and the controls to develop further understanding of the pathogenesis of SLE. Peripheral blood mononuclear cells were isolated from blood samples of 23 SLE patients, 10 idiopathic thrombocytopenic purpura patients and 10 healthy controls. The miRNA microarray chip analysis identified 16 miRNAs differentially expressed in SLE. The chip results were confirmed by northern blot analysis. This work indicates that miRNAs are potential diagnosis biomarkers and probable factors involved in the pathogenesis of SLE. Lupus (2007) 16, 936—946.

Key Words: human • SLE • microarray • microRNA • ITP

Lupus, Vol. 16, No. 12, 939-946 (2007)
DOI: 10.1177/0961203307084158


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				G. D. Sebastiani and M. Galeazzi Infection--genetics relationship in systemic lupus erythematosus Lupus, November 1, 2009; 18(13): 1169 - 1175. [Abstract] [PDF]

				F J Sheedy and L A J O'Neill Adding fuel to fire: microRNAs as a new class of mediators of inflammation Ann Rheum Dis, December 1, 2008; 67(Suppl_3): iii50 - iii55. [Abstract] [Full Text] [PDF]