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Lupus
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Response to tetanus vaccination in infants exposed in utero to immunosuppressants for maternal autoimmune disorders

R Cimaz

Hospices Civils de Lyon- Universitè Lyon 1, Lyon, France; Fondazione Policlinico Mangiagalli, Milano, Italy roland.cimaz{at}chu-lyon.fr

E Meregalli

M Biggioggero

Fondazione Policlinico Mangiagalli, Milano, Italy

P Airò

E Danieli

C M Antonioli

M Motta

G Chirico

D Columbrita

M Frassi

Spedali Civili Brescia, University of Milano, Italy

P L Meroni

University of Milano, Italy; Istituto Auxologico, Milano, Italy

A Tincani

Spedali Civili Brescia, University of Milano, Italy

Immunosuppressive drugs given during pregnancy to mothers suffering from a systemic autoimmune disease (AID) can cross the placenta, thus being potentially able to affect the offspring immune system. Aim of our study was to evaluate the in vivo immune function of a series of these newborns. Twenty-two babies born from mothers suffering from autoimmune diseases (AID) who had been taking immunosuppressive drugs during pregnancy were evaluated for their response to vaccination with C. Tetani toxoid. Six babies born from mothers receiving low-dose aspirin only were used as controls. The immune response to C. Tetani vaccination was evaluated with an ELISA to detect circulating antibodies. Five children out of 28 (17%) did not achieve a protective titer of anti C. Tetanitoxoid IgG. No clear relationship was found between specific drug exposure and antibody response. Our findings suggest that maternal immunosuppressive treatment given for a systemic AID can affect the response to an active immunization, without specificities for drug types used.

Key Words: immune function • immunosuppression • newborns • pregnancy • vaccination

Lupus, Vol. 16, No. 2, 129-132 (2007)
DOI: 10.1177/0961203306075738
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Home page
 Rheumatology (Oxford)Home page
M. Motta, A. Tincani, P. L. Meroni, and R. Cimaz
Follow-up of children exposed antenatally to immunosuppressive drugs
Rheumatology, June 1, 2008; 47(suppl_3): iii32 - iii34.
[Abstract] [Full Text] [PDF]


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