SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Lupus
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (9)
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Avalos, I
Right arrow Articles by Stein, C M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Avalos, I
Right arrow Articles by Stein, C M
Right arrowPubmed/NCBI databases
*Substance via MeSH
Medline Plus Health Information
*Lupus
*Pain
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Oxidative stress in systemic lupus erythematosus: relationship to disease activity and symptoms

I Avalos

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA; Divisions of Rheumatology and Clinical Pharmacology, T-3219 MCN, Vanderbilt University School of Medicine, 1161 21st Ave South Nashville, TN 37232-6248, USA; ingrid.avalos{at}vanderbilt.edu

C P Chung

A Oeser

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA

G L Milne

Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA

J D Morrow

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA

T Gebretsadik

A Shintani

C Yu

Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA

C M Stein

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA

Oxidative stress may play a role in the pathogenesis of systemic lupus erythematosus (SLE). We examined the hypothesis that oxidative stress was associated with indices of lupus disease activity and severity of symptoms. Urinary F2 isoprostane excretion, a validated marker of oxidative stress, was measured in 95 patients with SLE and 103 healthy controls. Outcome measures included SLEDAI and SLICC scores, the modified health assessment questionnaire, the fatigue severity scale (FSS), and visual analogue scales (VAS) for fatigue, pain and overall disease activity. F2 isoprostane excretion was compared in patients and controls, and its relationship with clinical variables in SLE examined. F2 isoprostane excretion did not differ significantly among patients with lupus (2.7 ± 2.3 ng/mg Cr) and control subjects (2.2 ± 1.4 ng/mg Cr) (P = 0.70). In patients with lupus, F2 isoprostane concentrations were independently associated with higher patient reported disease activity (VAS) (OR = 1.52, P = 0.01), fatigue (FSS, OR = 1.52, P = 0.03) and lower quality of life (OR = 0.73, P = 0.05), but not with objective markers or inflammation or disease activity. In conclusion, F2 isoprostane excretion is associated with patient-reported symptoms in SLE but not with measures of inflammation, SLEDAI or SLICC. Oxidative stress may contribute to debilitating symptoms such as fatigue in SLE.

Key Words: isoprostanes • oxidative stress • systemic lupus erythematosus

Lupus, Vol. 16, No. 3, 195-200 (2007)
DOI: 10.1177/0961203306075802


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
LupusHome page
I. Avalos, C. P. Chung, A. Oeser, G. L. Milne, H. Borntrager, J. D. Morrow, P. Raggi, J. Solus, and C. M. Stein
Aspirin therapy and thromboxane biosynthesis in systemic lupus erythematosus
Lupus, December 1, 2007; 16(12): 981 - 986.
[Abstract] [PDF]



Advertisement