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Lupus, Vol. 16, No. 6, 444-446 (2007)
DOI: 10.1177/0961203307077670

Myocardial infarction in a young man with antiphospholipid syndrome and cocaine use

E.L. Williams

Rheumatology Department, Southampton University Hospitals NHS Trust, Southampton, UK, emwilliams25{at}btinternet.co.uk

A.L. Endean

Rheumatology Department, Southampton University Hospitals NHS Trust, Southampton, UK

C.J. Edwards

Rheumatology Department, Southampton University Hospitals NHS Trust, Southampton, UK

The authors present a case of myocardial infarction in a 26-year-old man with antiphospholipid syndrome (APS) and a history of recent cocaine use. His only traditional cardiovascular risk was that he smoked. The authors propose that his cocaine use and APS brought about a potentially catastrophic cardiac event despite therapeutic anticoagulation. This was supported by the finding of normal coronary arteries on angiography despite both a significant regional wall motion abnormality on echocardiography and a significant rise in Troponin I. This case suggests the presence of a synergistic effect between cocaine and antiphospholipid antibodies. (Lupus (2007) 16, 444—446)

Key Words: antiphospholipid syndrome • cocaine • myocardial infarction


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