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Successful treatment of refractory neuroSjogren with Rituximab

Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon, yamoutba{at}idm.net.lb

T. El-Hajj

Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

W. Barada

Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

I. Uthman

Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

We report a 47-year-old female with Sjogren's syndrome (SS) and severe weakness in her lower extremities refractory to cyclophosphamide therapy, who was treated with the monoclonal anti CD-20 antibody rituximab at a weekly dose of 375 mg/m2 for four consecutive weeks. Patient responded within few days of the first dose and her motor power in the lower extremities started to improve gradually along with progressive resolution of the paresthesias and dysesthesias. The improvement was sustained and progressive and eight months after the last dose, she was able to walk for 60 meters without aid or rest. Rituximab may be considered as an effective and promising novel therapy in SS patients with neurological involvement. Lupus (2007) 16, 521—523.

Key Words: Neuro-Sjogren • Rituximab • Sjogren's syndrome

Lupus, Vol. 16, No. 7, 521-523 (2007)
DOI: 10.1177/0961203307078201


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