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Risk factors for amenorrhea in juvenile systemic lupus erythematosus (JSLE): a Brazilian multicentre cohort study

Pediatric Rheumatology Unit, University of São Paulo, clovisaas{at}icr.hcnet.usp.br

M.O. Hilário

Federal University of São Paulo

M.V. Febrônio

Pediatric Rheumatology Unit, University of São Paulo

S.K. Oliveira

Federal University of Rio de Janeiro

M.T. Terreri

Federal University of São Paulo

S.B. Sacchetti

Santa Casa of São Paulo

F.R. Sztajnbok

State University of Rio de Janeiro

R. Marini

State University of Campinas

M.V. Quintero

Santa Casa of Belo Horizonte

B.E. Bica

Division of Rheumatology, Federal University of Rio de Janeiro

R.M. Pereira

Division of Rheumatology, University of São Paulo

E. Bonfá

Division of Rheumatology, University of São Paulo

V.P. Ferriani

University of São Paulo, Ribeirão Preto

T.C. Robazzi

Hospital São Rafael-Bahia

C.S. Magalhães

São Paulo State University, Botucatu

We evaluated the prevalence and clinical associations of amenorrhea in 298 female juvenile systemic lupus erythematosus (JSLE) patients (ACR criteria) followed in 12 Brazilian Paediatric Rheumatology centres. Amenorrhea was observed in 35 patients (11.7%) with a mean duration of 7.2 ± 3.6 months. The hormones were performed in 32/35 patients and none of them had FSH and LH levels above and estradiol below the normal range according to pubertal changes. JSLE patients with amenorrhea were younger (15.04 ± 2.5 versus 17.8 ± 3.1 years; P = 0.001), and had a shorter period of time between menarche and current age (3.4 ± 2.9 versus 6.7 ± 5.4 years; P = 0.001). Interestingly, the frequency, cumulative dose, number of pulses and duration of intravenous cyclophosphamide treatment were alike in patients with and without amenorrhea (P > 0.05). In contrast, patients with amenorrhea had significantly higher SLEDAI (P = 0.01) and SLICC/ACR-DI (P = 0.024) scores compared to those without this condition. Independent risk factors identified by multivariate analysis were higher SLEDAI (OR = 1.059; CI = 1.004—1.116; P = 0.034) and SLICC/ACR-DI (OR = 2.125; IC = 1.373—3.291; P = 0.001) scores. Our data suggest that in spite of immunosuppressive therapy, JSLE patients have an adequate ovarian follicular reserve and amenorrhea is particularly associated with disease activity and damage. Lupus (2007) 16, 531—536.

Key Words: adolescent • amenorrhea • cyclophosphamide • gonadal function • juvenile systemic lupus erythematosus

Lupus, Vol. 16, No. 7, 531-536 (2007)
DOI: 10.1177/0961203307079300


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