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Immune function in children born to mothers with autoimmune diseases and exposed in utero to immunosuppressants

Department of Internal Medicine, University of Milan, IRCCS Istituto Auxologico Italiano, Milan

MO Borghi

Department of Internal Medicine, University of Milan, IRCCS Istituto Auxologico Italiano, Milan

M. Gerosa

Department of Internal Medicine, University of Milan, IRCCS Istituto Auxologico Italiano, Milan

L. Trespidi

IRCCS Policlinico, Mangiagalli & Regina Elena, Department for the Health of Mother, Child and Newborn, 2nd Clinic, Milan, Italy

R. Cimaz

Meyer Hospital, Florence, Italy

PL Meroni

Department of Internal Medicine, University of Milan, IRCCS Istituto Auxologico Italiano, Milan, pierluigi.meroni{at}unimi.it

The administration of immunosuppressive drugs during pregnancy is often necessary in women with autoimmune diseases. Teratogenicity of immunosuppressives during pregnancy has been evaluated, only few data exist about the effects on immune systems. We therefore performed a pilot study on the influence of foetal exposure to immunosuppressives on immune function of babies born to mothers with autoimmune disorders. We investigated serological and cellular parameters as indicators of immune system status. We included in the study 14 babies (mean age 11 months, range 1—24) born to mothers with autoimmune diseases and exposed in utero to different immunosuppressants and, as controls, 14 babies whose mothers had autoimmune manifestations but did not receive immunosuppressive therapy. We evaluated: (i) complete blood count, (ii) immunoglobulin levels and IgG subclasses, (iii) antibody response to hepatitis B vaccine, (iv) leukocyte subpopulations and (v) interleukin-2 and interferon in vitro production by resting or activated peripheral blood mononuclear cells. We did not find statistically significant differences between exposed and not exposed babies or among treatments for the tested parameters. Immunosuppressive regimens currently in use for controlling maternal autoimmune disorders do not significantly affect the immune status of the offspring. Lupus (2007) 16, 651—656.

Key Words: Autoimmunity • immunosuppressive therapy • pregnancy • neonatal immune system

Lupus, Vol. 16, No. 8, 651-656 (2007)
DOI: 10.1177/0961203307079569


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