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Flow cytometric assessment of anti-neuronal antibodies in central nervous system involvement of systemic lupus erythematosus and other autoimmune diseases

Division of Rheumatology, Department of Internal Medicine, Medical Research Center, Seoul National University, College of Medicine, Seoul, Republic of Korea

G.Q. Shen

Rheumatology Diagnostics Laboratory, Inc., Los Angeles, CA, USA

R. Morris

Rheumatology Diagnostics Laboratory, Inc., Los Angeles, CA, USA

A. Metzger

Rheumatology Diagnostics Laboratory, Inc., Los Angeles, CA, USA

E.Y. Lee

Division of Rheumatology, Department of Internal Medicine, Medical Research Center, Seoul National University, College of Medicine, Seoul, Republic of Korea

Y.J. Lee

Division of Rheumatology, Department of Internal Medicine, Medical Research Center, Seoul National University, College of Medicine, Seoul, Republic of Korea

E.B. Lee

Division of Rheumatology, Department of Internal Medicine, Medical Research Center, Seoul National University, College of Medicine, Seoul, Republic of Korea

Y.W. Song

Division of Rheumatology, Department of Internal Medicine, Medical Research Center, Seoul National University, College of Medicine, Seoul, Republic of Korea, ysong{at}snu.ac.kr

The objective of this study is to evaluate the association between anti-neuronal antibody (anti-NA) and central nervous system (CNS) manifestations of systemic lupus erythematosus (SLE) and other rheumatic diseases using a flow cytometric method. Anti-NA was measured by flow cytometry in serum and cerebrospinal fluid (CSF) samples from patients with SLE (n = 44 for serum, n = 17 for CSF), other rheumatic diseases (n = 64 for serum, n = 21 for CSF) and from healthy controls (n = 65 for serum, n = 18 for CSF). Serum anti-NA was more frequently observed in SLE (31.8%, 14/44) than in other rheumatic diseases (4.7%, 3/64, P < 0.001) or in healthy controls (0%, 0/65, P < 0.00001). In SLE patients, the frequency of serum anti-NA was significantly higher in CNS-SLE (76.5%, 13/17) than in non CNS-SLE (3.7%, 1/27, P < 0.000001). CSF anti-NA was detected in 88.2% (15/17) of CNS-SLE and was more frequently detected in CNS-SLE (15/17, 88.2%) than in other rheumatic diseases with CNS involvement (1/21, 4.8%, P < 0.000001) or in healthy controls (0/18, P < 0.000001). In conclusion, serum anti-NA was more frequently found in CNS-SLE than in non CNS-SLE, other rheumatic diseases or in healthy controls. The frequency of CSF anti-NA in CNS-SLE was significantly higher than in other rheumatic diseases with CNS involvement or in healthy controls. Lupus (2008) 17, 21—25.

Key Words: anti-neuronal antibody • central nervous system • lupus erythematosus • systemic

Lupus, Vol. 17, No. 1, 21-25 (2008)
DOI: 10.1177/0961203307085256


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