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Lupus, Vol. 17, No. 1, 26-33 (2008)
DOI: 10.1177/0961203307085246

Striking alteration of some populations of T/B cells in systemic lupus erythematosus: relationship to expression of CD62L or some chemokine receptors

T. Watanabe

Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan, ps-mind{at}wg7.so-net.ne.jp

J. Suzuki

Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan

A. Mitsuo

Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan

S. Nakano

Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan

Y. Tamayama

Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan

A. Katagiri

Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan

H. Amano

Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan

S. Morimoto

Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan

Y. Tokano

Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan

Y. Takasaki

Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan

Recent studies have revealed new populations of T/B cells, including central/effector memory, follicular T cells and CXCR3+ or CXCR4+ B cells. In the present study, changes in these populations of CD4+ T cells were examined on the basis of the expression of CD62L, CCR7 and CXCR5 in patients with systemic lupus erythematosus (SLE) in relation to CCL21 and CXCL10. Changes in CXCR3+, CXCR4+ and CXCR5+ B cells were also examined. CD62L and various chemokine receptors were examined by flow cytometry analysis using monoclonal antibodies, and CCL21 and CXCL10 were examined by sandwich enzyme-linked immunosorbent assay. In patients with SLE, a decrease of naive T cells and an increase in the ratio of activated effector memory T cells were associated with an increase of CCL21 and CXCL10 in serum, although the correlation was not significant. An increase in the ratio of CXCR3+ B cells was also recognized. These results suggest that naive T cells are transferred to lymphoid tissue by CCL21, and that effector memory T cells are activated by CXCL10. It is also suggested that B cells responsive to follicular helper T cells tend to migrate to inflammatory tissue.

Key Words: CD62L • chemokine receptor • effector memory T cell • follicular helper T cell • systemic lupus erythematosus


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