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Decreased CD4+CD25+bright T cells in peripheral blood of patients with primary Sjögren's syndrome

Section of Rheumatology and Immunology, Departments of Internal Medicine, Medical College, National Cheng Kung University, Tainan, Taiwan, Republic of China, mfliu{at}mail.ncku.edu.tw

L.-H. Lin

Section of Rheumatology and Immunology, Departments of Internal Medicine, Medical College, National Cheng Kung University, Tainan, Taiwan, Republic of China

C.-T. Weng

Section of Rheumatology and Immunology, Departments of Internal Medicine, Medical College, National Cheng Kung University, Tainan, Taiwan, Republic of China

M.-Y. Weng

Section of Rheumatology and Immunology, Departments of Internal Medicine, Medical College, National Cheng Kung University, Tainan, Taiwan, Republic of China

CD4⁺CD25 ^+bright T cells played a crucial role in the suppression of immune response. Recently, decreased levels of CD4⁺CD25^+bright T cells in the peripheral blood of patients with systemic lupus erythematosus were reported, suggesting the potential role of CD4⁺CD25^+bright T cells in human autoimmune diseases. Primary Sjögren's syndrome (pSS) is another common human systemic autoimmune disease. The present study aimed to investigate the levels of CD4⁺CD25^+bright T cells in pSS and to correlate their levels with some biomarkers of inflammation and immune activation. Thirty-three patients with pSS and 35 age- and sex-matched normal individuals were enrolled in the study. The flowcytometric method was applied in the measurement of CD4⁺CD25^+bright T cells. The results showed that patients with pSS had statistically lower levels of CD4⁺CD25^+bright T cells than normal controls, expressed either as absolute cell numbers (mean ± SD: 47.07 ± 25.53 cells/mm ³ versus 79.55 ± 34.56 cells/mm³, P < 0.001) or as percentages of peripheral blood mononuclear cells (mean ± SD: 2.79 ± 1.06% versus 3.84 ± 1.42%, P < 0.001) or as percentages of CD4⁺ T cells (mean ± SD: 7.85 ± 2.62% versus 11.68 ± 3.78%, P < 0.005). Moreover, there were statistically significant inverse correlations between the levels of CD4⁺CD25^+bright T cells and some parameters of inflammation or immune activation including erythrocyte sedimentation rate, C-reactive protein, IgG and rheumatoid factors. The result suggested that CD4⁺CD25^+bright T cells were likely to play anti-inflammatory and immunosuppressive roles in the pathogenesis of pSS. However, the exact functions of decreased circulating CD4⁺CD25^+bright T cells in pSS need further elucidated. Lupus (2008) 17, 34—39.

Key Words: CD4+CD25+ T cells • inflammation • primary Sjogren's syndrome

Lupus, Vol. 17, No. 1, 34-39 (2008)
DOI: 10.1177/0961203307085248


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