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Lupus, Vol. 17, No. 1, 6-10 (2008)
DOI: 10.1177/0961203307085879

Reviews

Review: Vitamin D, immunity and lupus

M. Cutolo

Research Laboratory and Academic Clinical Unit of Rheumatology, Department of Internal Medicine, University of Genova, Genova Italy, mcutolo{at}unige.it

K. Otsa

Department of Rheumatology, Tallinn Central Hospital, Tallinn, Estonia

The identification of vitamin D receptor in cells involved in the immune response and the discovery that activated dendritic cells produce vitamin D hormone suggested that vitamin D could exert immunoregulatory effects. Patients with autoimmune diseases such as multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus (SLE) show low 25-OH vitamin D serum levels. In particular, SLE patients have multiple risk factors for vitamin D deficiency and disease severity seems correlated with lower 25-OH vitamin D serum levels. Treatment of vitamin D deficiency could be particularly important in SLE patients due to concomitant insults on their tissues such as bone, and in view of the possible immunomodulatory effects exerted by vitamin D. Lupus (2008) 17, 6—10.

Key Words: immune response • systemic lupus erythematosus • vitamin D


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