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Lupus
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review-article

Genomics and proteomics: a new approach for assessing thrombotic risk in autoimmune diseases

C López-Pedrera

Unidad de Investigación, Hospital Universitario Reina Sofía, Cordoba, Spain

N Barbarroja

Unidad de Investigación, Hospital Universitario Reina Sofía, Cordoba, Spain

MA Aguirre

Unidad de Investigación, Hospital Universitario Reina Sofía, Cordoba, Spain

LA Torres

Unidad de Investigación, Hospital Universitario Reina Sofía, Cordoba, Spain

F Velasco

Unidad de Investigación, Hospital Universitario Reina Sofía, Cordoba, Spain

MJ Cuadrado

Lupus Research Unit, St Thomas Hospital, London, UK

Several systemic autoimmune conditions, including rheumatoid arthritis, systemic lupus erythematosus and antiphospholipid syndrome, are characterised by enhanced atherosclerosis and, consequently, higher cardiovascular morbidity and mortality rates. The association of these diseases with atherosclerosis suggests a common pathogenic mechanism. Genomic and proteomic studies performed on atherosclerotic plaques have further confirmed the presence of a gene and protein profile similar to that observed in autoimmune diseases with cardiovascular risks. Human sera and body fluids have been analysed and have resulted in the identification of auto-antibodies that can be used as diagnostic markers in specific autoimmune diseases, and proteomic fingerprints of blood cells, tissues and body fluids have resulted in the identification of individual proteins or patterns of protein expression that are deregulated. The information provided by these proteomic studies is of diagnostic and therapeutic potential. In this review, we discuss new approaches available for assessing thrombotic risk in autoimmune diseases, focusing in the genomic and proteomic methods now available to deep into the origin of the mechanisms associated with vascular involvement in systemic autoimmune diseases. The increasing data available suggests that when treating patients with these autoimmune disorders, paying attention to the increased risk of cardiovascular disease is essential.

Key Words: Autoimmune diseases • cardiovascular disease • genomics proteomics

Lupus, Vol. 17, No. 10, 905-916 (2008)
DOI: 10.1177/0961203308095285
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