This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Sestak, A. Articles by Harley, J. Search for Related Content PubMed PubMed Citation Articles by Sestak, A. Articles by Harley, J. Social Bookmarking                         What's this?

Patients with familial and sporadic onset SLE have similar clinical profiles but vary profoundly by race

Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA Andrea-Sestak{at}omrf.ouhsc.edu

SK Nath

Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA; Department of Pediatrics at the University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

JA Kelly

Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA

GR Bruner

Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA

JA James

Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

JB Harley

Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA; United States Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma, USA

Few large, multi-ethnic studies have examined the clinical and serologic differences between familial and sporadic SLE patients. Understanding these similarities and differences is critical for interpreting genetic studies and developing therapeutic strategies. We compiled information on 1915 patients with SLE in a large multi-racial cohort, including general demographics, pedigree structure and the specific American College of Rheumatology (ACR) criteria met. One patient was randomly selected from each multiplex family for analysis, yielding 554 European-Americans (EA), 373 African-Americans (AA), 193 Hispanics (HI) and 237 patients of other of mixed races. When comparing familial and sporadic patients stratified by race, lupus erythematosus (LE) cells and arthritis were increased in white familial cases (P = 5.5 x 10^–6 and P = 0.028, respectively), but no other significant differences between familial and sporadic patients were found. We found that there were profound differences in clinical profiles between races. For example, photosensitivity and malar rash were decreased in AA (P = 1.3 x 10^–13 and 1.4 x 10^–7, respectively), whereas discoid rash was increased in AA (P = 5.5x10^–6). EA had significantly less renal disease (P = 5.4x10^–13), proteinuria (P = 4 x 10^–12) and anti-Sm (P = 1.7 x 10^–12) than AA or HI. We, therefore, conclude that familial and sporadic onset patients may be treated similarly with respect to clinical and genetic studies.

Key Words: SLE • familial • sporadic • gender • race • clinical profile

Lupus, Vol. 17, No. 11, 1004-1009 (2008)
DOI: 10.1177/0961203308091969


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?