This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Shprecher, D Articles by Steffens, J Search for Related Content PubMed PubMed Citation Articles by Shprecher, D Articles by Steffens, J Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Lupus Hazardous Substances DB METHOTREXATE Social Bookmarking                         What's this?

Progressive multifocal leucoencephalopathy associated with lupus and methotrexate overdose

Department of Neurology, University of Rochester, Rochester, New York, USA david_shprecher{at}urmc.rochester.edu

T Frech

Department of Rheumatology, University of Utah Medical Center, Salt Lake City, Utah, USA

S Chin

Department of Neurology, University of Utah Medical Center, Salt Lake City, Utah, USA; Department of Pathology, University of Utah Medical Center, Salt Lake City, Utah, USA

R Eskandari

Department of Neurosurgery, University of Utah Medical Center, Salt Lake City, Utah, USA

J Steffens

Department of Neurology, University of Utah Medical Center, Salt Lake City, Utah, USA

Progressive multifocal leucoencephalopathy (PML) is a CNS infection of oligodendrocytes by JC virus, which rarely occurs in lupus, and can be mistaken for antiphospholipid antibody syndrome or neuropsychiatric systemic lupus erythematosus (NSLE). This case of PML in a patient with systemic lupus erythematosus on supra-therapeutic doses of methotrexate emphasises that CNS infection is an important diagnostic consideration before empiric treatment with immunosuppresants for NSLE.

Key Words: demyelinating disease • leucoencephalopathy • PML • systemic lupus erythematosus • viral infections

Lupus, Vol. 17, No. 11, 1029-1032 (2008)
DOI: 10.1177/0961203308089435


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				B. D. Korman, K. L. Tyler, and N. J. Korman Progressive Multifocal Leukoencephalopathy, Efalizumab, and Immunosuppression: A Cautionary Tale for Dermatologists Arch Dermatol, August 1, 2009; 145(8): 937 - 942. [Full Text] [PDF]