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Peripheral B cell abnormalities and disease activity in systemic lupus erythematosus

Charite, University Hospital Berlin, Berlin, Germany

AM Jacobi

Charite, University Hospital Berlin, Berlin, Germany

H Mei

Charite, University Hospital Berlin, Berlin, Germany

F Hiepe

Charite, University Hospital Berlin, Berlin, Germany

T Dörner

Charite, University Hospital Berlin, Berlin, Germany

Autoreactive B cells and plasma cells appear to be of central importance in the pathogenesis of systemic lupus erythematosus (SLE) characterized by a plethora of autoantibodies. Recent insights into abnormalities of B cell and plasma cell compartments in human SLE have identified a number of cellular disturbances within these compartments that in part correlate with the disease activity. This review discusses these findings and the potential underlying extrinsic and/or intrinsic influences apparently driving general B cell activation in this entity.

Key Words: B cell • B cell subpopulations • disease activity • systemic lupus erythematosus

Lupus, Vol. 17, No. 12, 1064-1069 (2008)
DOI: 10.1177/0961203308095138


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