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Aerobic capacity correlates to self-assessed physical function but not to overall disease activity or organ damage in women with systemic lupus erythematosus with low-to-moderate disease activity and organ damage

Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden, carina.bostrom{at}ki.se

B. Dupré

Rheumatology unit, Karolinska University Hospital, Solna, Sweden

P. Tengvar

Rheumatology unit, Karolinska University Hospital, Solna, Sweden

E. Jansson

Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, at Karolinska University Hospital (Huddinge), Stockholm, Sweden

CH Opava

Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden, Rheumatology unit, Karolinska University Hospital, Solna, Sweden

IE Lundberg

Rheumatology unit, Department of Medicine, Karolinska Institutet, at Karolinska University Hospital (Solna), Stockholm, Sweden

The present aim is to investigate the relationships between aerobic capacity and disease activity, organ damage, health-related quality of life (HRQL) and physical activity in 34 women with systemic lupus erythematosus (SLE) with low-to-moderate disease activity and organ damage. Mean age was 51 (SD 10) years, disease duration 17 (SD 11) years. Aerobic capacity (maximal oxygen uptake/VO₂ max) was measured with a bicycle ergometer exercise test. Overall disease activity was assessed with Systemic Lupus Activity Measure (SLAM) and the modified Systemic Lupus Erythematosus-Disease Activity Index (modified SLE-DAI), overall organ damage with the Systemic Lupus International Collaboration Clinics/American College of Rheumatology-Damage Index, [SLICC/(ACR)-DI], HRQL with the 36-item Short-form health-survey (SF-36) and physical activity with a self-assessed question. The women who were low-to-moderately physically active had 89—92% (P 0.001) of VO₂ max predicted for sedentary women. Maximal oxygen uptake (L/min, mL/min/kg) correlated to SF-36 physical function (r_s = 0.49, r_s = 0.72) (P 0.01), but not (r_s 0.25) to other HRQL scales, overall disease activity or organ damage or physical activity. The correlation between aerobic capacity and physical function and the absence of correlation between aerobic capacity and physical activity, suggest a possible disease-related factor behind the low aerobic capacity. However, with no correlation between aerobic capacity and overall disease activity and organ damage, low physical activity may contribute to the low aerobic capacity in our sample. Lupus (2008) 17, 100—104.

Key Words: oxygen uptake • physical activity • quality of life • systemic lupus erythematosus

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