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A/C polymorphism in the interleukin-18 coding region among Taiwanese systemic lupus erythematosus patients

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, Graduate Institute of Acupuncture Science, China Medical University, Taichung, Taiwan, Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan, Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan

L. Wan

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan, Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan, Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan

Jj-C Sheu

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan, Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan

C-M. Huang

Division of Immunology and Rheumatology, China Medical University Hospital, Taichung, Taiwan

C-W. Lin

Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan

Y-C. Lan

Department of Health Risk Management, China Medical University, Taichung, Taiwan

C-H. Lai

Department of Microbiology, School of Medicine, China Medical University, Taichung, Taiwan

C-H. Hung

Department of Microbiology, School of Medicine, China Medical University, Taichung, Taiwan

Y. Tsai

Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan

C-H. Tsai

Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan

T-H. Lin

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan

C-P. Chen

Department of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei, Taiwan

F-J. Tsai

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, d0704{at}www.cmuh.org.tw, Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan, Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan, Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan

Interleukin-18 (IL-18) is associated with chronic inflammation, autoimmune diseases and various cancers and infectious diseases. An IL-18 genetic A/C polymorphism at coding position 105 (rs549908) has been linked with asthma and rheumatoid arthritis. We tested a hypothesis that the IL-18 genetic polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Taiwanese SLE patients and a healthy control group. Our results indicate (1) a significantly higher A allele frequency in SLE patients (P = 0.003; OR = 1.97; 95% CI = 1.26—3.08) and (2) a significantly higher A allele frequency in SLE patients with a central nervous system disorder (P = 0.027; OR = 7.18; 95% CI = 0.95—54.28). Our results suggest that the A/C polymorphism contributes to SLE pathogenesis. Lupus (2008) 17, 124—127.

Key Words: interleukin-18 • single nucleotide polymorphism • systemic lupus erythematosus

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