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Lupus, Vol. 17, No. 2, 148-151 (2008)
DOI: 10.1177/0961203307084722

Contribution of polymorphism in codon 72 of p53 gene to systemic lupus erythematosus in Poland

P. Piotrowski

Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland

M. Lianeri

Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland

M. Mostowska

Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland

M. Wudarski

Institute of Rheumatology, Warsaw Poland

H. Chwalinska-Sadowska

Institute of Rheumatology, Warsaw Poland

PP Jagodzinski

Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland, pjagodzi{at}am.poznan.pl

The contribution of the p53 Arg72Pro polymorphism in the development of systemic lupus erythematosus (SLE) remains controversial. We investigated the frequency of the p53 Arg72Pro genotype in patients with SLE (n = 155) and in controls (n = 150) in Poland. We found a weak contribution of the Arg/Arg genotype to the morbidity of SLE. Odds ratio (OR) for patients with SLE and p53 Arg/Arg genotype was 1.875 [95% CI = 1.180—2.979], P = 0.0075 and OR of the Arg/Arg and Arg/Pro genotypes was 1.549 [95% CI = 0.752—3.195], P = 0.2328.

Since the p53Arg variant supports apoptosis better than the p53Pro variant, our findings can be linked to an increase in the number of apoptotic leucocytes in SLE patients. The distinction between various populations may be because of differences in racial composition and/or exposure to distinct environmental factors that have a different impact on SLE incidence along with the changed Argp53Pro genotype. Lupus (2008) 17, 148—151.

Key Words: p53 gene • polymorphism • systemic lupus erythematosus


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