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Sulpha allergy in lupus patients: a clinical perspective

College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA; Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA

G Bruner

Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA

S Glenn

Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA

P Sadanandan

Marion General Hospital, Marion, Indiana, USA

CW Carson

Oklahoma Arthritis Center, Edmond, Oklahoma, USA

JB Harley

Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA; US Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma, USA

AH Sawalha

Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA; US Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma, USA

Abstract

Systemic lupus erythematosus is a chronic, relapsing autoimmune disease that can affect multiple organ systems. An increased prevalence of drug allergy has been reported in lupus patients compared with the general population. Using a cohort of 417 lupus patients, we found a history of sulpha allergy in 27.3% of patients. European-American lupus patients with sulpha allergy are about two times more likely to suffer from lymphopenia, two times more likely to have anti-Ro autoantibody, and four times less likely to have anti-nRNP antibodies compared with lupus patients without a reported sulpha allergy (P = 0.0075, 0.025, and 0.032, respectively). In African-American lupus patients, a history of sulpha allergy was associated with over three times increased odds of developing pericarditis (P = 0.005).

Key Words: lupus • sulpha allergy • lymphopenia • pericarditis • serology

Lupus, Vol. 17, No. 3, 202-205 (2008)
DOI: 10.1177/0961203307086640


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