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Lupus, Vol. 17, No. 3, 206-209 (2008)
DOI: 10.1177/0961203307086235

case-report

Severe digital ischemia–a presenting symptom of malignancy–associated antiphospholipid syndrome

A Grossman

Department of Internal Medicine E, Rabin Medical Center, Beilinson Campus, Petach Tikva Israel. Affiliated to Sackler Medical School, Tel Aviv University, Tel Aviv, Israel

A Gafter-Gvili

Department of Internal Medicine E, Rabin Medical Center, Beilinson Campus, Petach Tikva Israel. Affiliated to Sackler Medical School, Tel Aviv University, Tel Aviv, Israel

H Green

Department of Internal Medicine E, Rabin Medical Center, Beilinson Campus, Petach Tikva Israel. Affiliated to Sackler Medical School, Tel Aviv University, Tel Aviv, Israel

I Ben Aharon

Davidoff Comprehensive Cancer Center, Rabin Medical Center, Beilinson Campus, Petach Tikva Israel. Affiliated to Sackler Faculty of Medicine School, Tel Aviv University, Tel Aviv, Israel

SM Stemmer

Davidoff Comprehensive Cancer Center, Rabin Medical Center, Beilinson Campus, Petach Tikva Israel. Affiliated to Sackler Faculty of Medicine School, Tel Aviv University, Tel Aviv, Israel

Y Molad

Unit of Rheumatology, Rabin Medical Center, Beilinson Campus, Petach Tikva Israel. Affiliated to Sackler Medical School, Tel Aviv University, Tel Aviv, Israel

I Krause

Department of Internal Medicine E, Rabin Medical Center, Beilinson Campus, Petach Tikva Israel. Affiliated to Sackler Medical School, Tel Aviv University, Tel Aviv, Israel

The association of the antiphospholipid syndrome with malignancy has been extensively reported. Raynaud’s phenomenon has also been reported to be associated with various malignancies. In this report, we describe two patients who presented with severe digital ischemia mimicking Raynaud’s phenomenon. The patients were found to have antiphospholipid syndrome, and upon extensive evaluation, a diagnosis of a malignancy was made. This report highlights the importance of malignancy workup in patients with severe digital ischemia associated with antiphospholipid syndrome.

Key Words: antiphospholipid syndrome • cancer • malignancy • Raynaud’s phenomenon


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