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Lupus
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review-article

Pathogenic role of antiphospholipid antibodies

JE Salmon

Department of Medicine, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, New York, USA

PG de Groot

Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, The Netherlands

Abstract

The antiphospholipid antibody syndrome (APS) is characterized by recurrent arterial and venous thrombosis and/or pregnancy in association with antiphospholipid (aPL) antibodies. The pathogenic mechanisms in APS that lead to in vivo injury are incompletely understood. Recent evidence suggests that APL antibodies alter regulation of haemostasis and induce activation of complement. We will discuss the current knowledge on how aPL antibodies trigger increased inflammation and enhanced thrombotic tendency, and thereby lead to tissue damage.

Lupus, Vol. 17, No. 5, 405-411 (2008)
DOI: 10.1177/0961203308090025
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