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Lupus
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What's this?

case-report

Cutaneous lichenoid graft-versus-host disease mimicking lupus erythematosus

R Goiriz

Departments of Dermatology and Pathology, Hospital Universitario de La Princesa, Madrid, Spain

PF Peñas

Departments of Dermatology and Pathology, Hospital Universitario de La Princesa, Madrid, Spain

Y Delgado-Jiménez

Departments of Dermatology and Pathology, Hospital Universitario de La Princesa, Madrid, Spain

J Fernández-Herrera

Departments of Dermatology and Pathology, Hospital Universitario de La Princesa, Madrid, Spain

M Aragüés-Montañés

Departments of Dermatology and Pathology, Hospital Universitario de La Princesa, Madrid, Spain

J Fraga

Departments of Dermatology and Pathology, Hospital Universitario de La Princesa, Madrid, Spain

A García-Díez

Departments of Dermatology and Pathology, Hospital Universitario de La Princesa, Madrid, Spain

Graft-versus-host disease (GVHD) is the main complication of allogeneic bone marrow transplantation and the skin is the most commonly involved organ. The clinical presentation is varied and may resemble autoimmune diseases, such as scleroderma, lichen planus or lichen sclerosus. Chronic GVHD presenting with a butterfly malar rash mimicking lupus erythematosus is uncommon. We report a series of five patients with cutaneous lichenoid GVHD that presented with a butterfly malar rash. Two of our patients had positive antinuclear antibody titres. The evolution was poor with development of sclerodermatous GVHD lesions in three patients and relapse of their haematological disease in two.

Key Words: chronic graft-versus-host disease • herpes zoster scars • lichenoid graft-versus-host disease • lupus erythematosus • sclerodermatous graft-versus-host disease • Wolf’s isotopic response

Lupus, Vol. 17, No. 6, 591-595 (2008)
DOI: 10.1177/0961203307087874
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