This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Abdwani, R Articles by El-Nour, I Search for Related Content PubMed PubMed Citation Articles by Abdwani, R Articles by El-Nour, I Social Bookmarking                         What's this?

Childhood systemic lupus erythematosus in Sultanate of Oman: demographics and clinical analysis

Department of Child Health, Sultan Qaboos University Hospital, Muscat, Oman, reemabd{at}hotmail.com

SG Rizvi

Family Medicine and Public Health Department, Sultan Qaboos University, Muscat, Oman

I El-Nour

Department of Child Health, Sultan Qaboos University Hospital, Muscat, Oman

There is a worldwide variation in the incidence of childhood manifestation of systemic lupus erythematosus, which may be related to environmental, genetic and geographical factors. The aim of the study is to describe for the first time the clinical and immunological characteristics of childhood onset systemic lupus erythematosus at diagnosis in the Sultanate of Oman. We retrospectively reviewed the records of 50 children with systemic lupus erythematosus fulfilling the American College of Rheumatology criteria between 1990 and 2006. There were 42 girls and eight boys. The mean age of disease onset was low at 8.6 years (SD 3.1). The female:male ratio was 5.3:1. The most frequent clinical manifestations at initial diagnosis were: articular (76%), cutaneous (70%), haematological (68%) and renal (64%) dominated by class IV nephritis, pulmonary (26%), neuropsychiatric (18%) and cardiac (10%). A positive antinuclear antibody (>1:80) was present in 94% at diagnosis. Positive anti–double stranded DNA was present in 82% and low complement levels were present in 84% at diagnosis. This is the first review of childhood onset systemic lupus erythematosus in the Sultanate of Oman.

Key Words: childhood onset systemic lupus erythematosus • Sultanate of Oman • Arab

Lupus, Vol. 17, No. 7, 683-686 (2008)
DOI: 10.1177/0961203307087611


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?