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Lupus, Vol. 17, No. 7, 687-694 (2008)
DOI: 10.1177/0961203308089439

research-article

Renal outcome and evolution of disease activity in Chinese lupus patients after renal transplantation

TM Yu

Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan

YH Chen

Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan

JL Lan

Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan

CH Cheng

Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Internal medicine, Chung-Shan Medical University, Taichung, Taiwan

CH Chen

Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan

MJ Wu

Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Internal medicine, Chung-Shan Medical University, Taichung, Taiwan

KH Shu

Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Internal medicine, Chung-Shan Medical University, Taichung, Taiwan, dmyou{at}vghtc.gov.tw

Lupus nephritis constitutes the major cause of morbidity and mortality in SLE. The long-term outcome of renal transplantation in lupus patients remains controversial, and the recurrence of lupus activity is a major concern. This study aims to determine the long-term outcome of renal transplantation in Chinese lupus patients and the evolution of lupus activity. A total of 23 lupus patients undergoing renal transplantation were enrolled and compared with 94 matched controls. The overall patient and graft survival rates at 10 years post-transplant in lupus group were not different from the control group (95.2% and 57.7% vs. 90.7% and 66.3%). Recurrence of lupus nephritis in renal allograft and flare-ups of lupus activity were not observed in this study. The SLE group had less acute rejection than the control group (20.4% vs. 29.8%, P < 0.05). The infection rate between the two groups was similar (39.1% vs. 51.1%, P = 0.427), although SLE group had a significantly higher rate of developing avascular necrosis (17.4% vs. 2.1%, P = 0.04). In conclusion, patient and graft survival rates and other major complications in Chinese lupus patients are comparable to non-lupus transplant recipients caused by other diseases. Chinese patients with SLE are suitable candidates for renal transplantation.

Key Words: lupus activity • outcome • renal transplantation • survival rate • systemic lupus erythematosus


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