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Genetic susceptibility and haplotype analysis between Fc receptor IIB and IIIA gene with systemic lupus erythematosus in Chinese population

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China

X Tang

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China

K Zhang

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China

X Li

Department of Rheumatology, Anhui Provincial Hospital, Hefei, China

J Xu

Department of Rheumato*logy, First Affiliated hospital, Anhui Medical University, Hefei, China

H Chen

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China

DQ Ye

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China, ydq{at}ahmu.edu.cn

The objective of this study is to understand the role of FcRIIB and FcRIIIA gene in susceptibility to systemic lupus erythematosus (SLE), and to examine possible susceptible haplotypes between two genes. A total of 119 patients with SLE from 95 nuclear families, aged from 14 to 78 years, were selected according to 1997 criteria of American College of Rheumatology. In addition, 316 family members of these patients were also genotyped. A family-based association study was used to explore the relationship between gene polymorphism and SLE. We studied 13 single-nucleotide polymorphisms (SNPs) encoding non-synonymous substitution in the FcRIIB and FcRIIIA gene (four SNPs in the FcRIIB gene and nine SNPs in the FcRIIIA gene) with respect to genetic susceptibility to SLE. All SNPs were genotyped by restriction fragment length polymorphism method. Among 13 SNPs, univariate (single-marker) family-based association tests showed that variant alleles at only four SNPs (rs10917661 and rs1050501, in exon 2 and exon 5 of FcRIIB gene, rs403016 and rs428888, in exon3 of FcRIIIA gene respectively) were significantly associated with genetic susceptibility to SLE. Furthermore, the haplotype-specific FBATs showed 50Ter-225Thr (34.1%, in FcRIIB gene) and 72Arg-118Asn (40%, in the FcRIIIA gene) haplotype were more frequently transmitted in SLE than other haplotypes (Z = 3.539, P = 0.00042; Z = 2.678, P = 0.007412 respectively). But haplotypes were not found between FcRIIB and FcRIIIA gene Our results suggest that there were meaningful haplotype in FcRIIIA and FcRIIB gene respectively. FcRIIIA and FcRIIB genes in the pathogenesis of SLE may play an independent role in Chinese population.

Key Words: Chinese • family based association test • FcRIIB • FcRIIIA • haplotype • lupus erythematosus • polymorphism • single nucleotide • systemic • susceptibility

Lupus, Vol. 17, No. 8, 733-738 (2008)
DOI: 10.1177/0961203308089407


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