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Metabolic syndrome in patients with systemic lupus erythematosus from Southern SpainSystemic Autoimmune Diseases Unit, Hospital Universitario Virgen de las Nieves, Granada, Spain jmasabio{at}gmail.com
Service of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada, Spain
Service of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada, Spain
Service of Prevention and Labour Health, Diputación de Granada, Hospital Xeral-Calde, Lugo, Spain
Service of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada, Spain
Department of Statistics, Hospital Universitario Virgen de las Nieves, Granada, Spain
Systemic Autoimmune Diseases Unit, Hospital Universitario Virgen de las Nieves, Granada, Spain
Division of Rheumatology, Hospital Xeral-Calde, Lugo, Spain
Systemic Autoimmune Diseases Unit, Hospital Universitario Virgen de las Nieves, Granada, Spain
The aim of this cross-sectional study was to establish the frequency, phenotype and characteristics of metabolic syndrome (MS), as defined by the Adult Treatment Panel III, in a cohort of patients with systemic lupus erythematosus (SLE) and its possible association with cardiovascular diseases (CVD). A total of 160 patients with SLE and 245 age, sex, educational level and ethnically matched controls were included. Association with cardiovascular risk factors, SLE features, treatment of SLE and history of CVD were assessed in patients with SLE and controls with and without MS. MS was non-significantly increased in patients with SLE (20%) compared with controls (13%; P = 0.083). It was more commonly observed in patients with SLE
Key Words: cardiovascular risk factors • metabolic syndrome • systemic lupus erythematosus
Lupus, Vol. 17, No. 9,
849-859 (2008) This article has been cited by other articles:
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40 years old (15.8%) than in controls of the same age group (4.2%; P < 0.001). The mean number of MS criteria was significantly higher among patients with SLE than in controls. The frequency of CVD was also 28-fold higher among patients with SLE (11.3%) than in controls (0.4%). SLE with MS presented higher levels of inflammatory markers than SLE without MS. In a multivariate analysis, educational level, serum triglycerides, HDL-cholesterol and C3 serum levels and hydroxychloroquine use were independently associated with MS. 
