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Anti–double stranded DNA and lupus syndrome induced by interferon-β therapy in a patient with multiple sclerosis

Institute of Allergy and Clinical Immunology, Clinical Center of Serbia, Belgrade, Serbia

I Jeremic

Institute of Biochemistry, School of Medicine, University of Belgrade, Belgrade, Serbia

S Andrejevic

Institute of Allergy and Clinical Immunology, Clinical Center of Serbia, Belgrade, Serbia sandrejevic{at}yahoo.com

M Sefik-Bukilica

Institute of Rheumatology, Resavska 69, Belgrade, Serbia

N Stojsavljevic

Institute of Neurology, Clinical Center of Serbia, Belgrade, Serbia

J Drulovic

Institute of Neurology, Clinical Center of Serbia, Belgrade, Serbia

We present a 43-year-old woman with relapsing–remitting multiple sclerosis (MS) who developed lupus syndrome after 32 months of IFN-β-1a therapy. She presented with malaise, myalgia, arthralgia and fever. Laboratory tests showed high erythrocyte sedimentation rate, anaemia and lymphopenia. Antibodies to double stranded DNA (dsDNA) of IgG, IgM and IgA classes were detected on Critidia luciliae. Additionally, high levels of anti-nucleosomal antibodies, low levels of anti-histone and anti-Ro/SSA antibodies were also found. Diagnosis of drug-induced SLE was established. Treatment with IFN-β was discontinued and oral prednisone was started. Twelve weeks after cessation of IFN-β therapy, the patient’s symptoms completely resolved and autoantibodies disappeared. To the best of our knowledge, this is the first report of a patient with MS in whom treatment with IFN-β induced lupus syndrome and antibodies to dsDNA and nucleosome.

Key Words: anti-dsDNA • IFN-β • lupus • multiple sclerosis

Lupus, Vol. 18, No. 1, 78-80 (2009)
DOI: 10.1177/0961203308093550


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