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Association of TNF- gene polymorphisms with systemic lupus erythematosus in Taiwanese patients

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan; Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwanyjlin{at}mail.cmu.edu.tw

R-H Chen

Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan; School of Post-Baccalaureate Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan

L Wan

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan; Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan

JJ-C Sheu

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan

C-M Huang

Division of Immunology and Rheumatology, China Medical University Hospital, Taichung, Taiwan

C-W Lin

Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan

S-Y Chen

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan

C-H Lai

Department of Microbiology, School of Medicine, China Medical University, Taichung, Taiwan

Y-C Lan

Department of Health Risk Management, China Medical University, Taichung, Taiwan

K-C Hsueh

Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan

C-H Tsai

Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan

T-H Lin

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan

Y-M Huang

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan

K Chao

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan

D-Y Chen

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan

F-J Tsai

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan; Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwanyjlin{at}mail.cmu.edu.tw

Tumour necrosis factor- (TNF-), an important proinflammatory cytokine, exerts a variety of physiological and pathogenic effects that lead to tissue destruction. Studies on the association of TNF- genetic polymorphisms with systemic lupus erythematosus (SLE) have yielded inconclusive results. We investigated the association of TNF- genetic polymorphisms (–1031T/C, –863C/A, –857T/C, –308A/G and +489A/G) with SLE in Taiwanese patients and controls. Our results indicate that 1) the frequency of the A-allele at –863 position was significantly higher in SLE patients (odds ratio = 1.46; 95% CI = 1.02–2.08); 2) the frequency of the A-allele at +489 position was significantly higher in SLE patients (odds ratio = 1.79; 95% CI = 1.21–2.65); 3) the AA or GA genotype frequencies at +489 position were significantly increased in SLE patients (AA genotype: odds ratio = 11.20; 95% CI = 1.36–92.55; GA genotype: odds ratio = 1.63; 95% CI = 1.03–2.58); 4) no significant association of TNF- haplotypic distributions was observed, except for the haplotypes TCCGA, CACGA and CCCGG; and 5) the genotype frequency of the polymorphisms at –1031 was significantly different in patients with antinuclear antibodies (P = 0.022). The allele and genotype frequencies of the polymorphisms at –863 were not significantly different. The genotype frequency of the polymorphisms at –857 was significantly different in patients with haematological disorder (P = 0.025). The frequency of A allele of the polymorphisms at –308 was significantly increased in patients with malar rash (P = 0.033), discoid rash (P = 0.023), photosensitivity (P = 0.037), oral ulcers (P = 0.002) and serositis (P = 0.029). The genotype frequency of the polymorphisms at +489 was significantly different in patients with discoid rash and photosensitivity (data not shown; discoid rash, P = 0.031; photosensitivity, P = 0.044). These results suggest that TNF- genetic polymorphisms contribute to SLE susceptibility in the Taiwanese population.

Key Words: single nucleotide polymorphism • systemic lupus erythematosus • tumour necrosis factor-

Lupus, Vol. 18, No. 11, 974-979 (2009)
DOI: 10.1177/0961203309105361


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