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Pathogenic role of anti-endothelial cell antibodies in autoimmune rheumatic diseases

Rheumatology Division, São Paulo University School of Medicine, São Paulo, Brazil

JF Carvalho

Rheumatology Division, São Paulo University School of Medicine, São Paulo, Brazil, Department of Internal Medicine B, Center for Autoimmune Diseases, affiliated to Tel-Aviv University Sackler Faculty of Medicine, Sheba Medical Center, Tel-Hashomer, Israel

Y. Shoenfeld

Department of Internal Medicine B, Center for Autoimmune Diseases, affiliated to Tel-Aviv University Sackler Faculty of Medicine, Sheba Medical Center, Tel-Hashomer, Israel, shoenfel{at}post.tau.ac.il

Anti-endothelial cells antibodies have been detected in numerous autoimmune and inflammatory diseases, including systemic lupus erythematous, rheumatoid arthritis, vasculitis and sarcoidosis. Anti-endothelial cells antibodies bind to endothelial cell antigens and induce endothelial damage. Their effects on the endothelial cell have been considered responsible, at least in part, by the vascular injury which occurs in these pathological conditions.

Key Words: anti-endothelial • endothelial cells • antibodies • pathogenesis • autoimmune diseases

Lupus, Vol. 18, No. 13, 1233-1238 (2009)
DOI: 10.1177/0961203309346654


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