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Circulating osteoprotegerin levels are elevated and correlated with antiphospholipid antibodies in patients with systemic lupus erythematosus

Department of Internal Medicine, Division of Rheumatology, St. Mary's hospital, The Catholic University of Korea, Seoul, Korea

YJ Shin

Department of Internal Medicine, Division of Rheumatology, St. Mary's hospital, The Catholic University of Korea, Seoul, Korea

HJ Kim

Department of Internal Medicine, Division of Rheumatology, St. Mary's hospital, The Catholic University of Korea, Seoul, Korea

HS Kim

Department of Internal Medicine, Division of Rheumatology, St. Mary's hospital, The Catholic University of Korea, Seoul, Korea

JY Kim

Department of Internal Medicine, Division of Rheumatology, St. Mary's hospital, The Catholic University of Korea, Seoul, Korea

SA Yoo

Department of Internal Medicine, Division of Rheumatology, St. Mary's hospital, The Catholic University of Korea, Seoul, Korea

JJ Choi

Department of Internal Medicine, Division of Rheumatology, St. Mary's hospital, The Catholic University of Korea, Seoul, Korea

WU Kim

Department of Internal Medicine, Division of Rheumatology, St. Mary's hospital, The Catholic University of Korea, Seoul, Korea

CS Cho

Department of Internal Medicine, Division of Rheumatology, St. Mary's hospital, The Catholic University of Korea, Seoul, Korea

Patients with antiphospholipid syndrome (APS) have an increased risk for the development of thrombotic complications. Recent studies indicate that osteoprotegerin (OPG) acts as an important molecule in the development of vascular diseases. The aim of the present study was to examine the association between serum OPG levels and APS manifestations in patients with SLE. Seventy-nine patients with SLE and ninety-two healthy controls, matched for age and sex, were included in this study. Serum levels of OPG, monocyte chemoattractant protein(MCP)-1 and soluble E-selectin were determined by ELISA. At the time of serum sampling, various clinical and laboratory parameters were assessed. We found that serum levels of OPG were significantly higher in patients with SLE than in healthy controls (1236 ± 82 vs 967 ± 37 pg/mL, P = 0.003). Particularly, serum OPG levels were significantly higher in SLE patients with APS than those without (1615 ± 191 vs 1171 ± 91 pg/mL, P = 0.006). Serum OPG levels correlated with titres of IgG anti-cardiolipin antibody (P = 0.026) and anti-β₂-glycoprotein I antibody (P < 0.001). Moreover, serum OPG also correlated with serum levels of sE-selectin (P = 0.002), which is an endothelial cell activation marker, and MCP-1 (P = 0.003), a well known chemokine implicated in thrombogenesis. Collectively, serum OPG levels were increased in SLE patients with APS and correlated with titres of antiphospholipid antibodies, suggesting that OPG might be linked to the development of APS.

Key Words: antiphospholipid antibody • MCP-1 • Osteoprotegerin • soluble E-selectin • systemic lupus erythematosus

Lupus, Vol. 18, No. 2, 133-138 (2009)
DOI: 10.1177/0961203308094819


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