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Influences on bone mineral density in Malaysian premenopausal systemic lupus erythematosus patients on corticosteroids

Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia yeapss{at}myjaring.net

AR Fauzi

Department of Medicine, Hospital University Kebangsaan Malaysia, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia

NCT Kong

Department of Medicine, Hospital University Kebangsaan Malaysia, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia

AG Halim

Department of Medicine, Hospital University Kebangsaan Malaysia, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia

Z Soehardy

Department of Medicine, Hospital University Kebangsaan Malaysia, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia

S Rahimah

Department of Medicine, Hospital University Kebangsaan Malaysia, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia

SK Chow

Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia

EML Goh

Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia

The aim of this study was to assess the bone mineral density (BMD) of premenopausal patients with systemic lupus erythematosus (SLE) on corticosteroids (CS) and to determine the influence of CS and other risk factors on BMD. A total of 98 premenopausal patients with SLE were recruited from outpatient clinics in two teaching hospitals. Risk factors for osteoporosis were determined, and BMD was measured using dual-energy x-ray absorptiometry. The mean age of the patients was 30.05 ± 7.54 years. The mean dose of prednisolone at time of BMD measurement was 18.38 ± 10.85 mg daily. Median duration of CS use was 2.5 years (range 0–20). Median cumulative dose of CS was 9.04 g (range 0.28–890.0). Six patients (6.1%) had osteoporosis, 41 (41.9%) had osteopenia and 51 (52.0%) had normal BMD. Lumbar spine T score correlated with cumulative CS dose (P = 0.019). Duration of CS intake correlated with femoral neck T score (P = 0.04) and trochanter T score (P = 0.008). There was no correlation between BMD and race, SLE Disease Activity Index score, smoking and self-reported calcium intake or exercise. Only 52% of these patients had normal BMD. The duration and cumulative dose of CS intake was significantly correlated to BMD, but not the other commonly assessed risk factors. These findings suggest that premenopausal patients with SLE on CS should have their BMD measured at regular intervals to fully assess their osteoporosis risk.

Key Words: bone mineral density • corticosteroids • osteoporosis • SLE

Lupus, Vol. 18, No. 2, 178-181 (2009)
DOI: 10.1177/0961203308094995


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