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Lupus and T Cells

Division of Rheumatology, Department of Medicine, University of California, Los Angeles, California, USA alacava{at}mednet.ucla.edu

T-cell abnormalities and aberrant T helper cytokine profiles have been implicated in the loss of immune tolerance to nuclear and cytoplasmic antigens and linked to a variety of clinical manifestations in systemic lupus erythematosus (SLE). Here, we review the role of T cells in promoting and maintaining SLE in relation to their cellular and molecular abnormalities and provide an update on recent T cell-targeted therapeutic approaches for the restoration of T cell homeostasis in the disease.

Key Words: systemic lupus erythematosus • anti-DNA antibodies • nephritis

Lupus, Vol. 18, No. 3, 196-201 (2009)
DOI: 10.1177/0961203308098191


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