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No evidence for genetic association of interferon regulatory factor 3 in systemic lupus erythematosus

Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain

MA González-Gay

Servicio de Reumatología, Hospital Xeral-Calde, Lugo, Spain

JL Callejas-Rubio

Servicio de Medicina Interna, Hospital Clínico San Cecilio, Granada, Spain

N Ortego-Centeno

Servicio de Medicina Interna, Hospital Clínico San Cecilio, Granada, Spain

JM Sabio

Servicio de Medicina Interna, Hospital Virgen de las Nieves, Granada, Spain

J Jiménez-Alonso

Servicio de Medicina Interna, Hospital Virgen de las Nieves, Granada, Spain

L Micó

Servicio de Medicina Interna, Hospital La Fe, Valencia, Spain

A Suarez

Departamento de Biología Funcional, Hospital Central de Asturias, Universidad de Oviedo, Oviedo, Spain

C Gutierrez

Departamento de Biología Funcional, Hospital Central de Asturias, Universidad de Oviedo, Oviedo, Spain

E de Ramón

Servicio de Medicina Interna, Hospital Carlos-Haya, Malaga, Spain

M Camps

Servicio de Medicina Interna, Hospital Carlos-Haya, Malaga, Spain

R Garcia-Portales

Servicio de Medicina Interna, Hospital Virgen de la Victoria, Malaga, Spain

C Tolosa

Servicio de Medicina Interna, Hospital Parc Taulí, Sabadell, Spain

MA López-Nevot

Servicio de Medicina Interna, Hospital Virgen de las Nieves, Granada, Spain

J Sánchez-Román

Servicio de Medicina Interna, Hospital Virgen del Rocío, Sevilla, Spain

FJ Hernández

Servicio de Medicina Interna, Hospital Virgen del Rocío, Sevilla, Spain

MF González-Escribano

Servicio de Inmunología, Hospital Virgen del Rocío, Sevilla, Spain

J Martín

Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain

The aim of this study was to determine the potential role of three IRF3 gene polymorphisms (rs2304204, rs7251 and rs2304207) with systemic lupus erythematosus (SLE). Our study population consisted of 610 patients with SLE and 730 healthy controls. All individual were of Spanish Caucasian origin. The IRF3 polymorphisms were genotyped using a PCR system with pre-developed TaqMan allelic discrimination assay. No statistically significant differences were found when allele and genotype distribution of rs2304204, rs7251 and rs2304207 polymorphisms were compared between patients with SLE and controls [overall P values: rs7251, P = 0.06; rs2304204, P = 0.26 and rs2304207, P = 0.36, by chi-squared test on a 3 x 2 contingency table. Overall allelic P values: rs7251, P = 0.8, OR (95%CI) = 1.03 (0.87–1.22); rs2304204, P = 0.2, OR (95%CI) = 1.12 (0.93–1.34) and rs2304207, P = 0.8, OR (95%CI) = 1.02 (0.82–1.26)]. In addition, no evidence of association with haplotypes and clinical features of SLE was found. Our data suggest that the IRF3 polymorphisms do not appear to play a major role in the susceptibility or severity of SLE in a Spanish population.

Key Words: autoimmune disease • IRF3 • polymorphisms • susceptibility • systemic lupus erythematosus

Lupus, Vol. 18, No. 3, 230-234 (2009)
DOI: 10.1177/0961203308096256


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