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Lupus
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case-report

Neonatal lupus in triplet pregnancy of a patient with undifferentiated connective tissue disease evolving to systemic lupus erythematosus

M Demaestri

Master Malattie Rare, Università degli Studi di Torino, Turin, Italy; Medicina d’Urgenza, Ospedale S. Lazzaro, Alba, Cuneo, Italy

S Sciascia

Immunologia Clinica e Allergologia, ASO Ospedale Mauriziano Umberto I, Turin, Italy savino.sciascia{at}alice.it

A Kuzenko

Immunologia Clinica e Allergologia, ASO Ospedale Mauriziano Umberto I, Turin, Italy

R Bergia

Immunologia Clinica e Allergologia, ASO Ospedale Mauriziano Umberto I, Turin, Italy

L Barberis

Divisione Neonatologia Ospedaliera ASO OIRM S. Anna, Turin, Italy

MG Lanza

Ginecologia Endocrinologica ASO OIRM S. Anna, Turin, Italy

MT Bertero

Master Malattie Rare, Università degli Studi di Torino, Turin, Italy; Immunologia Clinica e Allergologia, ASO Ospedale Mauriziano Umberto I, Turin, Italy

Pregnancy in patients suffering from undifferentiated connective tissue disease (UCTD) represents a risk situation for both the mother and the child. SSA/SSB autoantibodies can determine neonatal lupus (NL) in the foetus, regardless of the maternal disease. Furthermore, pregnancy increases the risk of flares and evolution to differentiated connective tissue disease (CTD). We report an uncommon case in which these complications occurred in a mother and in her foetuses. A 37-year-old woman affected by UCTD developed systemic lupus erythematosus (SLE) after her triplet pregnancy. The only manifestation of neonatal lupus we observed in the three newborns was SSA positivity associated with asymptomatic transient neutropenia.

Key Words: antiphospholipid syndrome • pregnancy • systemic lupus erythematosus

Lupus, Vol. 18, No. 4, 368-371 (2009)
DOI: 10.1177/0961203308097512
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