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Association of the HLA-G 14 bp polymorphism with systemic lupus erythematosus

Genetics Department, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Post-Graduation Program in Genetics and Molecular Biology, UFRGS, Porto Alegre, Brazil

EAA Cordero

Genetics Department, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

T Mucenic

Rheumatology Division, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil

OA Monticielo

Rheumatology Division, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil

JCT Brenol

Rheumatology Division, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil

RM Xavier

Rheumatology Division, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil

A Delgado-Cañedo

Laboratório de Cardiologia Molecular e Celular – Instituto de Cardiologia/Fundação Universitária de Cardiologia, Porto Alegre, RS, Brazil

JAB Chies

Genetics Department, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Post-Graduation Program in Genetics and Molecular Biology, UFRGS, Porto Alegre, Brazil jabchies{at}terra.com.br

Human leukocyte antigen-G (HLA-G) is a nonclassical class I major histocompatibility complex molecule which is induced at the course of inflammatory pathologies, and its expression has been suggested as a possible mechanism of tissue protection against autoimmune inflammatory responses, therefore acting as a mechanism of immune surveillance. We investigated the influence of the 14 bp polymorphism of the HLA-G gene on systemic lupus erythematosus (SLE) by analyzing 293 patients with SLE and 460 healthy controls. The patient’s group was not in Hardy–Weinberg equilibrium, presenting an excess of heterozygotes (P = 0.014). The heterozygote group exhibited lower systemic lupus erythematosus disease activity indexes than the homozygous deletion group and the homozygous insertion group (mean value = 2.29 against 2.97 and 3.4, respectively, P = 0.035). Photosensitive patients showed a higher frequency of heterozygotes and an equivalent lower frequency of homozygotes for deletion; on the other hand, patients without arthritis presented a higher frequency of heterozygotes than the arthritis group and also a lower frequency of the del/del genotype. Overall, our results support the idea of a role of the HLA-G insertion/deletion polymorphism and therefore a role for the HLA-G molecule, on the pathology of SLE.

Key Words: HLA-G • polymorphism • systemic lupus erythematosus

Lupus, Vol. 18, No. 5, 424-430 (2009)
DOI: 10.1177/0961203308098187


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