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Glu298Asp eNOS polymorphism is not associated with SLE

MD Postgraduate student: Medical Sciences; Universidade Federal do Rio Grande do Sul (UFRGS)

JCT Brenol

PhD in Medicine: Medical Sciences, UFRGS. Assistant Professor of the Internal Medicine Department, UFRGS jbrenol{at}hcpa.ufrgs.br

M Bredemeier

PhD in Medicine: Medical Sciences, UFRGS. Division of Rheumatology, Hospital de Clínicas de Porto Alegre

B Paiva dos Santos

Graduate student in Biological Sciences, UFRGS

JAB Chies

PhD in Life Sciences – Immunology, Paris VI University. Assistant Professor in the Genetics Department, UFRGS

OA Monticielo

MD Postgraduate student: Medical Sciences; Universidade Federal do Rio Grande do Sul (UFRGS)

RM Xavier

PhD in Immunology, Shimane University, Japan. Assistant Professor of the Internal Medicine Department, UFRGS

To examine potential associations of the Glu298Asp polymorphism in the coding region of the endothelial nitric oxide synthase (eNOS) gene with susceptibility to and clinical expression of systemic lupus erythematosus (SLE). One hundred thirteen consecutive patients of European ancestry with diagnosis of SLE, satisfying the American College of Rheumatology criteria, from the outpatient clinic of the Serviço de Reumatologia of the Hospital de Clínicas de Porto Alegre, and 206 healthy controls from the same geographic area were genotyped by polymerase chain reaction for the Glu298Asp polymorphism in the coding region of the eNOS gene. Clinical, demographic, and laboratorial data were collected. Clinical manifestations of SLE and related diseases were evaluated for the association with specific genotypes. The allelic and genotypic distribution of the Glu298Asp did not differ significantly between SLE patients and controls. We found no association of the polymorphism with lupus nephritis, antiphospholipid syndrome, cardiovascular disease (CVD), and risk factors to CVD. The presented results in this study do not provide support for a major role of eNOS Glu298Asp neither in the susceptibility for SLE or clinical manifestations, although there was low statistical power for the latter evaluation.

Key Words: endothelial nitric oxide synthase • eNOS • Glu298Asp • polymorphisms • systemic lupus erythematosus

Lupus, Vol. 18, No. 5, 448-451 (2009)
DOI: 10.1177/0961203308100510


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