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Molecular analysis of HLA-DRB1 allelic associations with systemic lupus erythematous and lupus nephritis in Taiwan

Departments of Nephrology, Mackay Memorial Hospital, Taipei; Departments of Mackay Medicine, Nursing and Management College, Taipei, Taiwan

CJ Wu

Departments of Nephrology, Mackay Memorial Hospital, Taipei

HH Chen

Departments of Nephrology, Mackay Memorial Hospital, Taipei

CW Dang

Departments of Medical Research, Mackay Memorial Hospital, Taipei

FM Chang

Departments of Medical Research, Mackay Memorial Hospital, Taipei

HF Liu

Departments of Medical Research, Mackay Memorial Hospital, Taipei

CC Chu

Departments of Medical Research, Mackay Memorial Hospital, Taipei

M Lin

Departments of Medical Research, Mackay Memorial Hospital, Taipei

YJ Lee

Departments of Medical Research, Mackay Memorial Hospital, Taipei; Department of Pediatrics, College of Medicine, Taipei Medical University, Taipei, Taiwan; Departments of Pediatrics, Mackay Memorial Hospital, Taipeiyannlee{at}ms2.mmh.org.tw

To evaluate the association of human leukocyte antigen (HLA)–DRB1 alleles with systemic lupus erythematosus (SLE) and lupus nephritis (LN) in the Taiwanese population, and to investigate the possible association of HLA-DRB1 alleles with disease severity in LN. HLA-DRB1 alleles were studied in 105 SLE patients (82 patients with LN, 23 patients without LN) and 855 healthy controls by polymerase chain reaction and sequence-based typing assays. The frequency of the HLA class II alleles DRB1*0301 (Odds ratio [OR] = 2.01, 95% confidence interval [CI] = 1.31–3.10, Pc = 0.02) and DRB1*1501 (OR = 2.06, 95% CI = 1.36–3.13, Pc = 0.01) were both increased in SLE patients, compared to healthy controls. The frequency of DRB1*1202 was significantly lower in LN patients than in SLE patients without nephritis (OR = 0.23, 95% CI = 0.09–0.57, Pc = 0.01). No specific allele was significantly associated with an increased or decreased risk for severity of LN in this sample. In Taiwanese people, the DRB1*0301 and DRB1*1501 alleles are significant risk factors for SLE, while the DRB1*1202 allele is protective for LN.

Key Words: HLA-DRB1 • lupus nephritis • SLE • Taiwanese

Lupus, Vol. 18, No. 8, 698-704 (2009)
DOI: 10.1177/0961203308101955


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