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Fc receptor IIB and IIIB polymorphisms and susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysis

Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korealyhcgh{at}korea.ac.kr

JD Ji

Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea

GG Song

Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea

The aim of this study was to explore whether polymorphisms of the Fc receptors (FcRs) IIB T/I232 and FcRIIIB NA1/NA2, confer susceptibility to systemic lupus erythematosus (SLE) and lupus nephritis (LN). The authors conducted a meta-analysis on associations between the FcRIIB T/I232 and FcRIIIB NA1/NA2 polymorphisms and SLE and LN susceptibility as determined using 1) allele contrast, 2) recessive, 3) dominant models and 4) contrast of homozygotes. A total of 16 separate comparisons were considered, consisting of 2887 SLE patients and 3105 controls. Meta-analysis of the FcRIIB T/I232 polymorphism showed a significant association between the FcRIIB T allele and the risk of developing SLE compared with the FcRIIB I allele (OR = 1.207, 95% CI = 1.061–1.373, P = 0.004). In subjects of Asian descent, a significant association was observed between the FcRIIB T allele and SLE (OR = 1.332, 95% CI 1.138–1.558, P < 0.001). However, in Europeans no such association was found. In contrast, no association was found between SLE or LN and the FcRIIIB NA1/NA2 polymorphism in all subjects, or in European and Asian populations. This meta-analysis shows that the FcRIIB T/I232 polymorphism confers susceptibility to SLE, especially in Asian-derived populations.

Key Words: Fc receptors • genetic polymorphism • meta-analysis • systemic lupus erythematosus

Lupus, Vol. 18, No. 8, 727-734 (2009)
DOI: 10.1177/0961203309104020


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