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Childhood stroke in a child with familial Mediterranean fever carrying several prothrombotic risk factors

Division of Hematology-Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon

KM Musallam

Division of Hematology-Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon

I Uthman

Division of Rheumatology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon

A Beydoun

Division of Neurology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon

T El-Hajj

Division of Neurology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon

AT Taher

Division of Hematology-Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanonataher{at}aub.edu.lb

Familial Mediterranean fever (FMF) was recently associated with a hypercoagulable state. However, clinically overt thrombosis remains a rare event limited to patients with other predisposing factors. We herein present a child with FMF who experienced a stroke. An extensive thrombophilia work-up revealed multiple inherited and acquired risk factors. In areas with high prevalence of prothrombotic mutations and in children who are products of consanguineous marriages, early screening for concurrent thrombotic risk factors is warranted; as this may help design an optimal management plan and prevent unfavourable outcomes.

Key Words: childhood • familial Mediterranean fever • thrombophilia • stroke

Lupus, Vol. 18, No. 9, 845-847 (2009)
DOI: 10.1177/0961203309103057


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