This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Haga, H.-J. Articles by Hughes, G. R.V. Search for Related Content PubMed PubMed Citation Articles by Haga, H.-J. Articles by Hughes, G. R.V. Pubmed/NCBI databases Substance via MeSH Medline Plus Health Information Lupus Social Bookmarking                         What's this?

Calprotectin in Patients with Systemic Lupus Erythematosus: Relation to Clinical and Laboratory Parameters of Disease Activity

Department of Rheumatology, Haukeland Hospital, Bergen

Johan G. Brun

Department of Rheumatology, Haukeland Hospital, Bergen

Hilde Berner Berntzen

Oslo Sanitetsforening Rheumatism Hospital, Oslo, Norway

Ricard Cervera

The Lupus Arthritis Research Unit, St Thomas' Hospital, London, UK

Munther Khamashta

The Lupus Arthritis Research Unit, St Thomas' Hospital, London, UK

Graham R.V. Hughes

The Lupus Arthritis Research Unit, St Thomas' Hospital, London, UK

Calprotectin (L1) is a granulocyte and monocyte cytosolic protein released during activation of these cells. The plasma level of L1 has been shown to be a good marker of disease activity in rheumatoid arthritis. In this cross-sectional study of 100 patients with systemic lupus erythematosus (SLE), the serum level of L1 was found to be higher in patients than in matched controls (3661 µg/l versus 1051 µg/l; P < 0.001). The serum level of L1 was the only laboratory parameter with significant association to the disease activity index SLEDAI (r = 0.28; P < 0.01). Furthermore, the serum level of L1 was significantly higher in SLE patients with anti-DNA antibodies compared to patients without anti-DNA antibodies (4501 µg/l versus 3279 µg/l; P = 0.01). SLE patients with arthritis had higher serum levels of L1 than patients without arthritis (7652 µg/l versus 2811 µg/l; P < 0.01), indicating that the serum level of L1 also reflects arthritis activity in SLE.

Key Words: Systemic lupus erythematosus • L1 protein • Calprotectin • C-reactive protein • Erythrocyte sedimentation rate • Disease activity

Lupus, Vol. 2, No. 1, 47-50 (1993)
DOI: 10.1177/096120339300200108


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				M. S. SOYFOO, J. ROTH, T. VOGL, R. POCHET, and G. DECAUX Phagocyte-specific S100A8/A9 Protein Levels During Disease Exacerbations and Infections in Systemic Lupus Erythematosus J Rheumatol, October 1, 2009; 36(10): 2190 - 2194. [Abstract] [Full Text] [PDF]

				J. M. Ehrchen, C. Sunderkotter, D. Foell, T. Vogl, and J. Roth The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer J. Leukoc. Biol., September 1, 2009; 86(3): 557 - 566. [Abstract] [Full Text] [PDF]

				Y Dai, C Hu, Y Huang, H. Huang, J Liu, and T Lv A proteomic study of peripheral blood mononuclear cells in systemic lupus erythematosus Lupus, September 1, 2008; 17(9): 799 - 804. [Abstract] [PDF]

				H. B. Hammer, S. Odegard, M. K Fagerhol, R. Landewe, D. v. d. Heijde, T. Uhlig, P. Mowinckel, and T. K Kvien Calprotectin (a major leucocyte protein) is strongly and independently correlated with joint inflammation and damage in rheumatoid arthritis Ann Rheum Dis, August 1, 2007; 66(8): 1093 - 1097. [Abstract] [Full Text] [PDF]

				D. Foell, H. Wittkowski, T. Vogl, and J. Roth S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules J. Leukoc. Biol., January 1, 2007; 81(1): 28 - 37. [Abstract] [Full Text] [PDF]

				C. Ryckman, K. Vandal, P. Rouleau, M. Talbot, and P. A. Tessier Proinflammatory Activities of S100: Proteins S100A8, S100A9, and S100A8/A9 Induce Neutrophil Chemotaxis and Adhesion J. Immunol., March 15, 2003; 170(6): 3233 - 3242. [Abstract] [Full Text] [PDF]

				M. Wahren, J.G. Brun, R. Jonsson, and H.-J. Haga Autoantibodies to calprotectin are not found in patients with systemic lupus erythematosus or other inflammatory rheumatic diseases Lupus, December 1, 1995; 4(6): 498 - 498. [PDF]