This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Shahram, F. Articles by Davatchi, F. Search for Related Content PubMed PubMed Citation Articles by Shahram, F. Articles by Davatchi, F. Social Bookmarking                   What's this?

Salmonella Infection in Systemic Lupus Erythematosus

Connective Tissue Diseases Research Unit, Rheumatology Research Center, Tehran University for Medical Sciences, Shariati Hospital, Kargar Ave., Tehran 14114, Iran

Mahmood Akbarian

Connective Tissue Diseases Research Unit, Rheumatology Research Center, Tehran University for Medical Sciences, Shariati Hospital, Kargar Ave., Tehran 14114, Iran

Fereydoun Davatchi

Connective Tissue Diseases Research Unit, Rheumatology Research Center, Tehran University for Medical Sciences, Shariati Hospital, Kargar Ave., Tehran 14114, Iran

Patients with systemic lupus erythematosus (SLE) are susceptible to infections, notably salmonellosis. We report 37 cases of salmonella infection in 24 patients with SLE. These cases were detected in a group of 770 patients with SLE. All the patients were women, with a mean age of 25.6 years. At the onset of salmonella infection, 81 % were taking prednisolone and 27 % were taking cytotoxic drugs. Renal involvement was present in 75% of patients, which was approximately the same as in other SLE patients. Bacteremia, arthritis, osteomyelitis and rare manifestations of salmonellosis, including pulmonary and urinary tract involvement, were encountered. Diagnosis was based on isolation of the microorganism, mostly from blood cultures. Salmonella species other than typhi and paratyphi were often responsible. Widal agglutination test was positive in less than half the cases, and leukopenia was not seen frequently. Recurrence of infection in 29% of the patients and the high mortality rate (28.5%), despite the conventional period of appropriate antimicrobial treatment, show a poor prognosis of salmonellosis in SLE patients. This special picture of salmonellosis argues for a much longer period of treatment in these patients.

Key Words: SLE • Salmonellosis • Infection

Lupus, Vol. 2, No. 1, 55-59 (1993)
DOI: 10.1177/096120339300200110


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				K.M. Chiu, T.Y. Lin, J.S. Chen, and S.H. Chu Rupture of renal artery aneurysm due to salmonella infection in a patient with systemic lupus erythematosus Lupus, February 1, 2008; 17(2): 135 - 138. [Abstract] [PDF]

				F Joshua, J Riordan, and A Sturgess Salmonella typhimurium mediastinal abscess in a patient with systemic lupus erythematosus Lupus, September 1, 2003; 12(9): 710 - 713. [Abstract] [PDF]

				E Lim, W-H Koh, S-F Loh, M-S Lam, and H-S Howe Non-thyphoidal salmonellosis in patients with systemic lupus erythematosus. A study of fifty patients and a review of the literature Lupus, February 1, 2001; 10(2): 87 - 92. [Abstract] [PDF]

				S. M. Sultan, Y. Ioannou, and D. A. Isenberg A review of gastrointestinal manifestations of systemic lupus erythematosus Rheumatology, October 1, 1999; 38(10): 917 - 932. [Abstract] [Full Text] [PDF]

				H. Howe, J. Wong, Z. Ding, C. Sivathasan, B. Ang, W. Koh, and P. Feng Mycotic aneurysm of a coronary artery in SLE a rare complication of salmonella infection Lupus, January 1, 1997; 6(4): 404 - 407. [Abstract] [PDF]