This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Yamamoto, T. Articles by Honda, N. Search for Related Content PubMed PubMed Citation Articles by Yamamoto, T. Articles by Honda, N. Social Bookmarking                   What's this?

Interstitial Inflammatory and Chronic Tubulointerstitial Lesions in Lupus Nephritis: Comparison with Those in IgA Nephropathy

First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu

Mitsumasa Nagase

First Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan

Akira Hishida

First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu

Nishio Honda

First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu

The significance of interstitial inflammatory and chronic tubulointerstitial lesions was studied in relation to the severity of glomerular lesions in 62 patients with lupus nephritis and 88 with IgA nephropathy. Severe interstitial inflammatory and chronic tubulointerstitial lesions were found in patients with severe glomerular lesions in both lupus nephritis and IgA nephropathy. In such cases, the serum creatinine levels at biopsy were high and the renal prognosis was poor regardless of the underlying disease (lupus nephritis or IgA nephropathy). No IgA nephropathy patients with nil or mild glomerular lesions had moderate or severe interstitial inflammatory and/or chronic tubulointerstitial lesions. In contrast, predominantly severe interstitial inflammatory lesions were found in 36% of lupus nephritis patients with nil or mild glomerular lesions. The prevalence of interstitial immune complexes deposition was markedly high in those with predominant interstitial inflammatory lesions. However, the severity of chronic tubulointerstitial lesions was mild and renal function did not deteriorate in the mean follow-up periods of 68.6 months. It is suggested that, besides the tubulointerstitial lesions attributable to the severe concomitant glomerular damage, the interstitial deposition of immune complexes per se plays a pathogenic role in the interstitial inflammatory lesions in lupus nephritis. Its prognostic significance, however, was considered to be minor.

Key Words: Tubulointerstitial nephritis • Lupus nephritis • IgA nephropathy

Lupus, Vol. 2, No. 1 suppl, 261-268 (1993)
DOI: 10.1177/096120339300200114


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?