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Lupus
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Anti-Intrinsic Factor Antibodies in Systemic Lupus Erythematosus

Jordi Junca

Service of Haematology, Hospital Germans Trias i Pujol, Badalona, Barcelona, ES

Alfons Cuxart

Service of Internal Medicine, Hospital Germans Trias i Pujol, Badalona, Barcelona, ES

Alejandro Olive

Service of Rheumatology, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

Cristina Tural

Service of Internal Medicine, Hospital Germans Trias i Pujol, Badalona, Barcelona, ES

As the co-existence of pernicious anaemia (PA) and systemic lupus erythematosus (SLE) has been repeatedly reported, we have investigated the presence of anti-intrinsic factor antibodies (IFAb), the immunological hallmark of PA, in patients diagnosed with SLE. Serum cobalamin levels and IFAb were determined in 30 women diagnosed with SLE as well as in 45 controls. Cobalamin levels were low in 7/30 patients. IFAb were detected in 3/30 sera from patients but in none of the control sera. The presence of IFAb was associated with a low cobalamin concentration, anaemia and macrocytosis in only one patient. There was no evident relationship between the presence of IFAb and serological markers of SLE. We conclude that IFAb may appear in SLE patients, although the cobalamin deficiency described in SLE seems to be due to the presence of IFAb in only a minority of cases.

Key Words: Systemic lupus erythematosus • Cobalamin • Anti-intrinsic factor antibodies

Lupus, Vol. 2, No. 2, 111-114 (1993)
DOI: 10.1177/096120339300200208
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[Abstract] [PDF]


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