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Lupus
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Amyotrophic Lateral Sclerosis in a Patient ivith Systemic Lupus Erythematosus

Xavier Forns

Systemic Autoimmune Diseases Research Unit, Department of Internal Medicine, University of Barcelona Barcelona, ES

Xavier Bosch

Systemic Autoimmune Diseases Research Unit, Department of Internal Medicine, University of Barcelona Barcelona, ES

Francesc Graus

the Service of Neurology, Hospital Clínic Provincial, University of Barcelona, Barcelona, Spain

Margarita Navarro

Systemic Autoimmune Diseases Research Unit, Department of Internal Medicine, University of Barcelona Barcelona, ES

Josep Font

Systemic Autoimmune Diseases Research Unit, Department of Internal Medicine, University of Barcelona Barcelona, ES

We report the case of a 48-year-old woman diagnosed as having systemic lupus erythematosus who developed a neurological disorder that finally resulted in amyotrophic lateral sclerosis. Although neurological disturbances caused by systemic lupus erythematosus are protean, there are no reported cases of amyotrophic lateral sclerosis associating with lupus disease. This association and the suspected autoimmune mechanism of pathogenesis in amyotrophic lateral sclerosis suggest that this might not be a simple coincidence but perhaps a causal relationship.

Key Words: Systemic lupus erythematosus • Amyotrophic lateral sclerosis • Gangliosides • Motor neuron disease

Lupus, Vol. 2, No. 2, 133-134 (1993)
DOI: 10.1177/096120339300200212
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