This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Stephansson, E.A. Articles by Lokki, M.-L. Search for Related Content PubMed PubMed Citation Articles by Stephansson, E.A. Articles by Lokki, M.-L. Social Bookmarking                         What's this?

HLA Antigens and Complement C4 Allotypes in Patients with Chronic Biologically False Positive (CBFP) Seroreactions for Syphilis: A Follow-Up Study of SLE Patients and CBFP Reactors

Department of Dermatology, Karolinska Institute, Stockholm, Sweden

S. Koskimies

Finnish Red Cross Blood Transfusion Service, Helsinki, Finland

M.-L. Lokki

Finnish Red Cross Blood Transfusion Service, Helsinki, Finland

We report a follow-up of our previous study of HLA markers in 118 unrelated patients: 49 with definite systemic lupus erythematosus (SLE) (group 1), 32 with definite or probable SLE and chronic biologically false positive (CBFP) seroreactions for syphilis (group 2), and 37 CBFP reactors (group 3). Definite SLE was confirmed in 28 (90.3%) of the patients in group 2, equally in HLA B8- and HLA B7-positive patients. Three of the CBFP reactors developed SLE, two (40%) out of five HLA B8-positive as compared to one (6.6%) out of 15 HLA By-positive CBFP reactors (P = 0.07). Fourteen patients died (groups 1 and 2). Eight of the 24 HLA B8-positive patients died in contrast to one of the 20 HLA B7-positive patients (P < 0.02).

Of the CBFP reactors, 70.9% had complement C4 null alleles as compared to 47.9% in controls (P = 0.05) and 50% had C4A null alleles as compared to 17.8% in controls (P < 0.05). C4B null alleles were found in 28.6% (28.6% in controls, P is not significant). The null alleles for C4A were not solely in a linkage disequilibrium with the HLA B8 DR3 haplotype. CBFP reactors with C4A null alleles had a higher risk of developing SLE, lupus-like disease or symptoms such as photosensitivity, cutaneous vasculitis and/or autoantibodies than did those with no C4A null alleles (P < 0.02).

Key Words: HLA and complement markers • Antiphospholipid antibodies • SLE • CBFP reactors

Lupus, Vol. 2, No. 2, 77-81 (1993)
DOI: 10.1177/096120339300200203


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				M. Galeazzi, G. D. Sebastiani, A. Tincani, J.-C. Piette, F. Allegri, G. Morozzi, F. Bellisai, R. Scorza, G. B. Ferrara, C. Carcassi, et al. HLA class II alleles associations of anticardiolipin and anti b2GPI antibodies in a large series of European patients with systemic lupus erythematosus Lupus, January 1, 2000; 9(1): 47 - 55. [Abstract] [PDF]